Publications
Books and special issues of scientific journals
| El Alzheimer Ana Martínez ISBN: 978-84-8319-427-0 Madrid, 2009 |
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Medicinal Chemistry of Alzheimer’s Disease. A. Martinez, Ed., Transworld Research Network, Kerala 2008. |
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| Glycogen synthase kinase 3 (GSK-3) and its inhibitors: Drug discovery and developments. A. Martinez, A. Castro, M. Medina Eds. Wiley-Interscience, New Jersey 2006. |
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Alzheimer’s Disease: Targets for Drug Development. A. Martinez, Ed., Mini Rev Med Chem 1 (2) 2002. |
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| Advances in Alzheimer Therapy: Understanding Pharmacological Approaches to the disease A. Martinez, D.K. Lahiri, E. Giacobini, N.H. Greig, Eds., Curr. Alzheimer Res. 6 (2) 2009. |
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D. I. Perez, F. van Rantwijk, R. A. Sheldon. Chloroperoxidase Cross-Linked Enzyme Aggregates (CLEAs): synthesis, optimization and characterization. Adv. Synt. Catalysis, 2009, 351, 2133-2139.
D. I. Perez, S. Conde, C. Pérez, C. Gil, D. Simon, F. Wandosell, F. J. Moreno, F. J. Luque, J. L. Gelpí, A. Martínez. Thienylhalomethylketones: Irreversible GSK-3 inhibitors as useful pharmacological tools. Bioorg. Med. Chem., 2009, 17, 6914-6925.
G. Ermondi, G. Caron, M. Pérez, D. I. Pérez, Z. Gándara, A. Martínez, G. Gómez, Y. Fall. Inhibitors of non-ATP competitive glycogen synthase kinase 3 beta (GSK-3β) potential drugs for the treatment of Alzheimer disease: QSAR studies for a consistent data set of palinurin-related structures. Bioorg. Med. Chem. 2009, submitted
M. Pérez, D. I. Pérez, A. Martínez, A. Castro, G. Gómez, Y. Fall. The first enantioselective synthesis of palinurin. Chem. Commun., 2009, 3252-3254.
A. Martínez, D.K. Lahiry, E. Giacobini. N. Greig. Advances in Alzheimer Therapy: Understanding pharmacological approaches to the disease. Curr. Alzheimer Res. 6, 83-85 (2009)
M.I. Fernandez-Bachiller, C. Perez, N. Campillo, J.A. Paez, G. Gonzalez-Muñoz, P. Usán, E. Garcia-Palomero, S. Conde, M. G. Lopez, M. Villarroya, A.G. Garcia, A. Martinez, M.I. Rodriguez-Franco. Design, synthesis, docking studies, and biological evaluation of tacrine-melatonin hybrids with cholinergic, antioxidant, and neuroprotective properties: new multifunctional agents for Alzheimer’s disease. ChemMedChem. 4, 828-841 (2009)
T. Castaño, H. Wang, N.E. Campillo, S. Ballester, C. Gonzalez-Garcia, J. Hernandez, C. Perez, J. Cuenca, A. Perez-Castillo, A. Martinez, O. Huertas, J.L. Gelpi, F.J. Luque, H. Ke, C. Gil. Synthesis and biological evaluation of thioxoquinazoline derivatives as new phosphodiesterase 7 and 4 dual inhibitors. ChemMedChem. 4, 866-876 (2009)
T. Valero, L del Barrio, J. Egea, N. Cañas, A. Martinez, AG Garcia, M. Villaroya, MG Lopez. NP04634 prevents cell damage by calcium overload and mitochondrial disruption in bovine chromaffin cells. Eur. J. Pharmacol. 607, 47-53 (2009)
T. Castaño, A. Encinas, C. Pérez, A. Castro, N.E. Campillo, C. Gil. Design, synthesis and evaluation of potential inhibitors of nitric oxide synthase, Bioorg. Med. Chem. 2008, 16, 6193-6206.
A. Castro, M.J. Jerez, C. Gil, F. Calderón, T. Doménech, A. Nueda, A. Martínez. CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example. Eur J Med Chem. 43, 1349-59 (2008).
A. Castro, A. Encinas, C. Gil, S. Bräse, W. Porcal, C. Pérez, FJ Moreno, A. Martínez. Non-ATP competitive glycogen synthase kinase 3beta (GSK-3beta) inhibitors: study of structural requirements for thiadiazolidinone derivatives. Bioorg Med Chem. 16, 495-510 (2008).
A.O. Rosa, J. Egea, A. Martínez, A.G. García, M.G. López. Neuroprotective effect of the new thiadiazolidinone NP00111 against oxygen-glucose deprivation in rat hippocampal slices: implication of ERK1/2 and PPAR-gamma receptors. Exp Neurol. 212, 93-99 (2008).
E. García-Palomero, P. Muñoz, P. Usan, P. Garcia, E. Delgado, C. De Austria, R. Valenzuela, L. Rubio, M. Medina, A. Martínez. Potent beta-amyloid modulators. Neurodegener Dis. 5, 153-156, (2008).
A.O. Rosa, M.P. Kaster, R.W. Binfaré, S. Morales, E. Martín-Aparicio, M.L. Navarro-Rico, A. Martinez, M. Medina, A.G. García, M.G. López, A.L. Rodrigues. Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice. Prog Neuropsychopharmacol Biol Psychiatry. 32, 1549-56 (2008).
R. Luna-Medina, M. Cortés-Canteli, S. Sanchez-Galiano, JA Morales-Garcia, A. Martinez, A. Santos, A. Perez-Castillo. NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. J Neurosci. 23, 5766-5776 (2007).
M. Hamann, D. Alonso, E. Martín-Aparicio, A. Fuertes, MJ. Pérez-Puerto, A. Castro, S. Morales, ML. Navarro, M. Del Monte-Millán, M. Medina, H. Pennaka, A. Balaiah, J. Peng, J. Cook, S. Wahyuono, A. Martínez. Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease. J Nat Prod. 70, 1397-405 (2007).
M. del Monte-Millán, E. García-Palomero, R. Valenzuela, P. Usán, C. de Austria, P. Muñoz-Ruiz, L. Rubio, I. Dorronsoro, A. Martínez, M. Medina. Dual binding site acetylcholinesterase inhibitors: potential new disease-modifying agents for AD. J Mol Neurosci. 30, 85-88 (2006).
K.V. Rao, M.S. Donia, J. Peng, E. Garcia-Palomero, D. Alonso, A. Martinez, M. Medina, S.G. Franzblau, B.L. Tekwani, S.I. Khan, S. Wahyuono, K.L. Willett, M.T. Hamann. Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases. J Nat Prod. 69, 1034-1040 (2006).
P. Muñoz-Ruiz, L. Rubio, E. Garcia-Palomero, I. Dorronsoro, M. Monte-Millán, R. Valenzuela, P. Usán, C. De Austria, M. Bartolini, V. Andrisano, A. Bidon-Chanal, M. Orozco, F. J. Luque, M. Medina, A. Martinez. Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: New disease-modifying agents for Alzheimer´s disease. J. Med. Chem. 48, 7223-7233 (2005).
A. Martinez, M. Alonso, A. Castro, I. Dorronsoro , J.L. Gelpí, J. Luque, C. Perez, F. Moreno. SAR and 3D-QSAR studies on TDZDs derivatives: Exploration of structural requirements for GSK-3 inhibitors. J. Med. Chem. 48, 7103-7112 (2005).
M.I. Rodríguez-Franco, I. Fernández-Bachiller, C. Pérez, A. Castro, A. Martínez. Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase. Bioorg Med Chem. 13, 6795-6802 (2005).
C. Gil, I. Dorronsoro, A. Castro, A. Martinez. Good oral absorption prediction on non-nucleoside benzothiadiazine dioxide human cytomegalovirus inhibitors using combined chromatographic and neuronal network techniques. Bioorg. Med. Chem. Lett. 2005, 15, 1919-1921.
C. Gil, S. Bräse. Efficient Solid-Phase Synthesis of Highly Functionalized 1,4 Benzodiazepin-5-one Derivatives and Related Compounds via Intramolecular Aza-Wittig Reactions, Chem. Eur. J. 2005, 11, 2680-2688.
D. Alonso, I. Dorronsoro, L. Rubio, P. Muñoz, E. Garcia-Palomero, M. del Monte, A. Bidon-Chanal, M. Orozco, F.J. Luque, A. Castro, M. Medina, A. Martinez. Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE. Bioorg. Med. Chem. 13, 6588-6597 (2005)
R. Luna-Medina, M. Cortés-Canteli, M. Alonso, A. Santos, A. Martinez, A. Perez-Castillo. Regulation of inflammatory response in neural cells in vitro by TDZDs derivatives through PPARg activation. J. Biol. Chem. 280, 21453-21462(2005)
I.Dorronsoro, D. Alonso, A. Castro, M. del Monte, E. García-Palomero, A. Martínez. Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetylcholinesterase inhibitors. Arch Pharm. 338, 18-23 (2005).
C. Gil, A. Schwögler, S. Bräse. Synthesis of 3-substituted 6-aryl-3H-benzo[a][1,2,3]triazinones using Polymer-bound Triazenes, J. Comb. Chem. 2004, 6, 38-42.
I.Dorronsoro, A. Chana, M.I. Abasolo, A. Castro, C. Gil, M. Stud, A. Martinez. CODES/Neural network model: a useful tool for in silico prediction of oral absorption and blood-brain barrier permeability of structurally diverse drugs, QSAR Comb. Sci. 2004, 23, 89-98.
S. Conde, D. I. Pérez, A. Martínez, C. Pérez, F.J. Moreno. Thienyl and phenyl a-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3) from a library of compounds searching. J. Med. Chem. 46, 4631-4633(2003).
A. Martinez, M. Alonso, A. Castro, C. Perez, F.J. Moreno. First non-ATP competitive GSK-3beta inhibitors: Thiadiazolidinones as potential drugs for the treatment of Alzheimer’s disease. J. Med. Chem., 45, 1292-1299 (2002)
A. Martínez, C. Gil, A. Castro, C. Pérez, C. Prieto, J. Otero. Benzothiadiazine Dioxides (BTD) Derivatives as Non-Nucleoside Human Cytomegalovirus (HCMV) Inhibitors. Study of Structural Requirements for Biological Activity, Bioorg. Med. Chem. 2003, 11, 2395-2402.
A.Martínez, C. Gil, A. Castro, A.M. Bruno, C. Pérez, C. Prieto, J. Otero. Benzothiadiazine Dioxide (BTD) Human Cytomegalovirus (HCMV) Inhibitors: Synthesis and Antiviral Evaluation of Main Heterocycle Modified Derivatives, Antiv. Chem. & Chemother. 2003, 14, 107-114.
A. Martínez, C. Gil, A. Castro, C. Pérez, M. Witvrouw, C. Pannecouque, J. Balzarini, E. De Clerq. Anti HIV-1 activity of Benzothiadiazine Dioxides, Antiv. Chem. & Chemother. 2002, 12, 347-351.
A. Castro, M.I. Abasolo, C. Gil, V. Segarra, A. Martinez. CoMFA of benzyl derivatives of 2,1,3-benzo and benzothieno[3,2-alpha]thiadiazine 2,2-dioxides: clues for the design of phosphodiesterase 7 inhibitors. Eur J Med Chem. 36, 333-338 (2001).
A. Martinez, E. Fernandez, A. Castro, S. Conde, M.I. Rodriguez-Franco, J.E. Baños, A. Badia. N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors. Eur J Med Chem. 35, 913-922 (2000).
M.I. Rodríguez-Franco, I. Dorronsoro, A. Martínez, C. Pérez, A. Badía, J.E. Baños. Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties. Arch Pharm. 333, 118-122 (2000).
A. Martínez, C. Lanot, C. Pérez, A. Castro, P. López-Serrano, S. Conde. Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives. Bioorg Med Chem. 8, 731-738 (2000).
A. Martínez, A. Castro, C. Gil, M. Miralpeix, V. Segarra, T. Doménech, J. Beleta, J.M. Palacios, H. Ryder, X. Miró, C. Bonet, J.M. Casacuberta, F. Azorín, B. Piña, P. Puigdoménech. Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: first phosphodiesterase 7 inhibitors. J Med Chem. 43, 683-689 (2000).
A. Martinez, D. Alonso, A. Castro, V.J. Arán, I. Cardelús, J.E. Baños, A. Badia. Synthesis and potential muscarinic receptor binding and antioxidant properties of 3-(thiadiazolyl)pyridine 1-oxide compounds. Arch Pharm. 332, 191-194 (1999).
Reviews and Chapters
C. Gil, S. Bräse. Solid-Phase Synthesis of Biologically Active Benzoannelated Nitrogen Heterocycles: An Update. J. Comb. Chem. 11, 175-197, (2009).
C. Gil, N. E. Campillo, D. I. Pérez, A. Martínez. Phosphodiesterase 7 (PDE7) inhibitors as new drugs for neurological and anti-inflammatory disorders. Exp. Opin. Ther. Patents 18, 1127-1139, (2008)
A. Martinez, D. I. Perez. GSK-3 Inhibitors: A Ray of Hope for the Treatment of Alzheimer's Disease?. J Alzheimers Dis. 15, 181-191 (2008).
A. Martinez. Preclinical efficacy on GSK-3 inhibitors: Towards a future generation of powerful drugs. Med Res Rev. 28, 773-796 (2008).
A. Castro, P. Muñoz, A. Martinez. Dual binding site acetylcholinesterase inhibitors: Design, SAR, and potential role as new disease modifying agents for Alzheimer’s disease, in Medicinal Chemistry of Alzheimer’s Disease. A. Martinez, Ed. , Transworld Research Network, Kerala 2008, pp. 21-44.
A. Martinez, M. Alonso, A. Castro, I. Dorronsoro. GSK-3 Inhibitors in Alzheimer’s disease: TDZDs, from discovery to clinical trials, in Medicinal Chemistry of Alzheimer’s Disease. A. Martinez, Ed. , Transworld Research Network, Kerala 2008, pp. 225-253.
A. Martinez. Marine-derived drugs in neurology. Curr Opin Investig Drugs. 8, 525-530 (2007)
D. Alonso, A. Martinez. Marine compounds as a new source for glycogen synthase kinase 3 inhibitors, in Glycogen synthase kinase 3 (GSK-3) and its inhibitors: Drug discovery and developments. A. Martinez, A. Castro, M. Medina Eds., Wiley-Interscience, New Jersey 2006, pp 307-331.
A. Castro, M. Alonso, A. Martinez. TDZDs: Selective and ATP noncompetitive glycogen synthase kinase 3 inhibitors, in Glycogen synthase kinase 3 (GSK-3) and its inhibitors: Drug discovery and developments. A. Martinez, A. Castro, M. Medina Eds.,Wiley-Interscience, New Jersey 2006, pp 257-280.
A.Castro, A. Martinez. Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors. Curr Pharm Des. 12, 4377-87 (2006)
A. Castro, A. Martinez. Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer´s disease. Exp. Opin. Investig. Drugs 15, 1-12 (2006)
A. Castro, T. Castaño, A. Encinas, W. Porcal, C. Gil. Advances on the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles. Bioorg. Med. Chem. 14, 1644-1652, (2006).
S. Bräse, C. Gil, K. Knepper, V. Zimmermann. Organic azides: an exploding diversity of a unique class of compounds. Angew. Chem. Int. Ed. 44, 5188-5240 (2005).
A. Castro, M.J. Jerez, C. Gil, A. Martinez. Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors. Med Res Rev. 25, 229-244 (2005).
M. Alonso, A. Martínez. GSK-3 inhibitors: discoveries and developments. Curr. Med. Chem., 11, 755-763 (2004).
C. Gil, S. Bräse. Traceless and multifunctional linkers for the generation of small molecules on solid supports. Curr. Opin. Chem. Biol. 8, 230-237 (2004).
K. Knepper, C. Gil, S. Bräse. Linkers for solid phase chemistry in Highlights in Bioorganic Chemistry. Ed. C. Schmuck, H. Wennemers, Wiley-VCH. 2004, 449-484.
C. Gil, K. Knepper, S. Bräse. Organic Synthesis on Polymeric Supports in Polymeric Materials in Organic Synthesis and Catalysis. Ed. M. Buchmeiser, Wiley-VCH. 2003, 137-199.
K. Knepper, C. Gil, S. Bräse. Natural product-like and other biologically active heterocyclic libraries in the post-genomic era using solid-phase techniques. Comb. Chem. High T. Scr. 6, 673-691 (2003).
S. Morales-Alcelay, L. Rubio, A. Martinez. AMPA glutamate receptors and neuropathic pain. Mini Rev Med Chem. 3, 757-763 (2003).
I. Dorronsoro, A. Castro, A. Martínez. Peripheral and dual-binding site acetylcholinesterase inhibitors as neurodegenerative disease modifying agents. Exp. Opin. Ther. Pat., 13, 1725-1732 (2003).
I. Dorronsoro, A. Castro, A. Martinez. Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs?. Exp. Opin. Ther. Pat, 12, 1539-1544 (2002)
A. Martinez, A. Castro, I. Dorronsoro, M. Alonso. GSK-3 inhibitors as promising drugs for the treatment of Alzheimer disease, cancer, diabetes and inflammation. Med. Res. Rev., 22, 373-384 (2002).
A. Castro, S. Conde, M.I. Rodriguez-Franco, A. Martinez. Non-cholinergic pharmacotherapy approaches to the future treatment of Alzheimer's disease. Mini Rev Med Chem. 2, 37-50 (2002).
S. Bräse, C. Gil, K. Knepper. The Recent Impact of Solid-Phase Synthesis on Medicinally Relevant Benzoannelated Nitrogen Heterocycles. Bioorg. Med. Chem. 10, 2415-2437, (2002).
S. Conde b-Amyloid peptide as a target for treatment of Alzheimer's disease. Expert. Opin. Ther. Patents 2002, 12, 503-512.
A. Martinez, A. Castro, C. Gil, C. Perez. Recent strategies in the development of new human cytomegalovirus inhibitors. Med. Res. Rev. 3, 227-244 (2001).
A. Castro, A. Martinez. Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease. Mini Rev Med Chem. 1, 267-272 (2001).
Reviews and chapter
D. I. Perez, C. Gil, A. Martinez. “Tau protein kinases inhibitors: from the bench to the clinical trials” in Emerging Drugs and Targets for AD. Ed. A. Martinez, Royal Society of Chemistry. 2009, chapter 9.
Pérez, D. I.; Gil, C.; Martínez, A. Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases. Med. Res. Rev. 2009, 000.
